【拟研究或解决的问题】
1．左奥硝唑代谢产物M1合成路线研究
2．左奥硝唑代谢产物M1检测图谱分析
3．合成反应副产物探究
【研究手段】
1．通过研究奥硝唑的合成手段构建M1的合成路线
The constant interest in nitroimidazoles was originally caused by the discovery of the naturally occurring antibiotic Azomycin (2-nitroimidazole).Concerning their activity against pathogenic microorganisms, several investigations towards structure-activity relationships of this substance class were accomplished and led to 1-aikylated 4- and 5-nitroimidazoles, which showed the 5-nitrocompounds were more effective than their 4-nitro isomers.The screening of several substitution patterns of the nitroimidazoles elicited Metronidazole and Ornidazole
2．4-硝基咪唑(M1-1)酸性条件下反应为M1-2
⑴ 反应条件与试剂：
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