缓控释制剂的研究进展摘要： 缓释制剂(sustainedreleflse system) ，也称长效制剂或延效制剂，顾名思义，是通过某种合适的方法来延缓药物在体内发生作用的时间的一种给药系统，其中包括释放、吸收、代谢、排泄，其药物释放主要为一级速率过程。
主耍类型有：生物溶蚀性骨架制剂、不溶性骨架试剂、亲水凝胶骨架制剂及缓释包衣制剂等而缓控释制剂(controlledrelease system）是指用适当的方法在预定的时间内以预定的速度的释放药物在体内的作用过程，并使药物浓度在体内保持长时间恒定，动力学为零级或接近零级释药。
与一些普通制剂相比，缓控释制剂给药频率至少减少一半或有所减少，能增加患者的依从性，其中控释制剂比缓释制剂的血药浓度更加平稳。
控释不仅包含缓释作用，而且药物的释放也控制在某一个固定的值范围上。
其动力学比缓释制剂也更有目的性和重现性。
往往有时把靶向给药系统、透皮给药系统、黏膜给药系统、植入给药系统等也归属于广义的控释制剂范畴。
缓控释制剂有许多的特点，它能够减少给药次数并增加疗效，不减少药物总量，降低不良反应，并与其它药物相比，资金投入少，方便，风险小，利润丰厚，是未来药物发展的一个很有前景的方向。
临床实践发现，一些慢性病患者在用普通制剂进行治疗时依从性差。
关键词：缓控释制剂、作用、原理与方法、制备与工艺、高分子Abstract: Sustained-releflse system, also called long-acting or delayed-effect formulation, as the name suggests, is a drug delivery system that delays the action of drugs in the body through a suitable method, including release and absorption. Metabolism, excretion, and drug release are primarily primary rate processes. Main types include: bioerodible skeleton preparations, insoluble skeleton agents, hydrophilic gel skeleton preparations and sustained-release coating preparations, etc. and controlled release systems means using appropriate methods within a predetermined time The release of the drug at a predetermined rate of action in the body, and maintain the drug concentration in the body for a long time constant, the kinetics of zero or nearly zero grade release. Compared with some common preparations, the frequency of administration of sustained-release preparations is at least reduced by half or decreased, which can increase the compliance of patients. The controlled-release preparations have a more stable blood concentration than sustained-release preparations. Controlled release not only contains a sustained release effect, but also the release of the drug is controlled over a fixed range of values. Its kinetics are also more objective and reproducible than sustained release formulations. Targeted drug delivery systems, transdermal drug delivery systems, mucosal drug delivery systems, and implantable drug delivery systems are also sometimes included in the broad sense of controlled release formulations. Sustained-controlled release preparations have many characteristics. They can reduce the number of administrations and increase the efficacy. They do not reduce the total amount of drugs and reduce adverse reactions. Compared with other drugs, they have less capital investment, are convenient, have little risk, and are lucrative. They are the future. A promising direction for drug development. Clinical practice has found that some patients with chronic diseases have poor compliance when treated with common preparations.Keywords: Sustained-controlled release formulation,;action; principle and method; preparation and process; polymer一、缓控释制剂1.1缓控释制剂在药物中发挥的作用有(1) 能使血药浓度平稳，避免峰谷现象，有利于降低药物的毒副作用，可保证其安全性及有效性，特别是对治疗窗窄的药物而言。
