文献综述
摘 要：临床调查表明，依诺肝素钠是目前抗凝血、抗血栓形成的首选治疗药物，其发展前景广阔，因此，对于产品中的杂质要求非常仔细。通过查阅相关文献，本文主要综述了药品依诺肝素钠、离子色谱法的相关资料以及研究历史，以此为依据来开发并验证依诺肝素钠中乙酸根及氯离子的含量检测，从而控制药品中的杂质。
关键词：依诺肝素钠；离子色谱；乙酸根；氯离子
Abstract：Clinical investigation shows that enoxaparin sodium is currently the first choice of anticoagulant, anti-thrombosis treatment of drugs, its broad prospects for development. Therefore, for the impurities in the product requirements are very careful. By reviewing the relevant literatures, this paper reviews the data of enoxaparin sodium and ion chromatography as well as the research history. Based on this, we develop and verify the content of acetate and chloride ions in enoxaparin sodium in order to controlling the impurities in the drug.
Key Words：Enoxaparin sodium；Ion chromatography；Acetate；Chloride
1. 依诺肝素钠药品的简介
依诺肝素钠，英文名称：Enoxaparin Sodium，是由猪肠粘膜提取的肝素钠经酯化后得到的肝素苄基酯钠衍生物，通过碱裂解生成的低分子量肝素钠，它的化学结构式如下图所示：
